Irf2bp2a regulates terminal granulopoiesis through proteasomal degradation of Gfi1aa in zebrafish.
The ubiquitin-proteasome system plays important roles in various biological here processes as it degrades the majority of cellular proteins.Adequate proteasomal degradation of crucial transcription regulators ensures the proper development of neutrophils.The ubiquitin E3 ligase of Growth factor independent 1 (GFI1), a key transcription repressor go